منابع مشابه
Effects of hexamethonium and decamethonium on end-plate current parameters.
The effects of neuromuscular blocking concentrations of hexamethomum and decamethonium on end-plate current parameters have been studied in frog sartorius nervemuscle preparations. In the presence of either drug, hyperpolarization of the cell membrane reduces the peak amplitude of the end-plate current despite the increase in driving force. The effect is larger for hexamethonium than for decame...
متن کاملDescendants of decamethonium.
W ITH perhaps one exception, decamethonium has been the parent of the main neuromuscular blocking agents introduced, since its discovery, for clinical trial as muscle-relaxants. Its descendants (see fig. 1) include suxamethonium (succinylcholine), suxethonium (362 I.S.), Ro 3-0386 and Laudolissin. The exception (fig. 2) is benzoquinonium (Mytolon), which was derived from an experimental anti-ba...
متن کاملDecamethonium iodide: a reappraisal.
DECAMETHONIUM iodide (CIO) was first described by Barlow and Ing, and by Paton and Zaimis, in 1948. The following year it was introduced into anaesthesia as a result of the work of Organe, and of Hewer, Lucas, Prescott and Rowbotham. Apart from the initial enthusiasm decamethonium has never found much favour with anaesthetists. In 1950 an editorial in the Lancet, comparing it with Gallamine, st...
متن کاملHexamethonium and glaucoma.
THIS investigation was undertaken in an endeavour to decide if the methonium ganglion blocking compounds could be administered to cases of vascular hypertension who were known to be suffering from glaucoma, or to similar vascular hypertensive cases of a glaucomatous disposition although this might not be known, without the danger of subsequent sequelae such as an increase in intra-ocular pressu...
متن کاملInotropic action of hexamethonium.
The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1950
ISSN: 0007-0912
DOI: 10.1093/bja/22.4.218